ENN’s Technical Brief on simplified approaches to wasting treatment aims to achieve greater coverage and improved efficiency of services. In response to challenges in the current model of care — high costs, limited access to treatment services, parallel supply chains for therapeutic food products, and disparate treatment protocols — as well as acceleration by the COVID-19 pandemic, adaptations to simplify treatment delivery have become critical. ENN outlines the critical elements of simplified approaches, where they are being used, and evidence for implementation.